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Huai-ying "Kay" Hsi Ph.D. Student
Department of Chemical Engineering Massachusetts Institute of Technology Room: E19-532 77 Massachusetts Ave. Cambridge, MA 02139
Phone: (617) 324-8460 Fax: (617) 253-2072 E-mail: hyhsi@mit.edu
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Education:
- Ph.D. Candidate, Chemical Engineering – Massachusetts Institute of Technology, Cambridge, Massachusetts – Projected Degree Conferral: December, 2012
- M.S. Chemical Engineering - Massachusetts Institute of Technology, Cambridge, Massachusetts – June, 2010
- B.S. Chemical Engineering - National Taiwan University, Taipei, Taiwan - May, 2007
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Research summary:
My Ph.D. thesis comprises the study and optimization of separation processes in pharmaceutical industries. The main goal is to avoid solid handling and increase the selectivity of traditional crystallization processes. I study the purification of intermediates and final active pharmaceutical ingredients (APIs) using selective impurity co-crystal formation or impurity complex formation in the solution. A strategy was designed to select the optimal co-former, solvent, and co-former concentration to achieve the best separation for a specific system. I am also exploring the possibility to purify the intermediates/APIs using self-assembled monolayers (SAMs).
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Keywords:
Crystallization, co-crystals, separation processes, SAMs
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The Myerson Group, 77 Massachusetts Ave, Rm 66-568, Cambridge, MA 02139 | Phone: 617-452-3790 | Email: myerson@mit.edu
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